Journal article
Myostatin in the placentae of pregnancies complicated with gestational diabetes mellitus
HN Peiris, M Lappas, HM Georgiou, K Vaswani, C Salomon, GE Rice, MD Mitchell
Placenta | W B SAUNDERS CO LTD | Published : 2015
Abstract
Introduction Gestational diabetes mellitus (GDM) is characterised by maternal glucose intolerance and insulin resistance during pregnancy. Myostatin, initially identified as a negative regulator of muscle development may also function in the regulation of placental development and glucose uptake. Myostatin expression in placentae of GDM complicated pregnancies is unknown. However, higher myostatin levels occur in placentae of pregnancies complicated with preeclampsia. We hypothesise that myostatin will be differentially expressed in GDM complicated pregnancies.Methods Myostatin concentrations (ELISA) were evaluated in plasma of presymptomatic women who later developed GDM and compared to pla..
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Grants
Awarded by Diabetes Australia Research Trust
Funding Acknowledgements
This work was supported by funding from the Diabetes Australia Research Trust (Y13G-MITM). Associate Professor Martha Lappas is supported by a Career Development Fellowship by the National Health and Medical Research Council (NHMRC; grant no. 1047025). The following are gratefully acknowledged: the clinical Research Midwives Genevieve Christophers, Renee Grant, Gabrielle Fleming, Debra Jinks and Rachel Murdoch for sample collection; and the Obstetrics and Midwifery staff of the Mercy Hospital for Women for their co-operation.